Brad E Sleebs Selected Research

plasmepsin (plasmepsin I)

1/2020	Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle.
6/2018	Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.
8/2015	Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
7/2014	Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

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Brad E Sleebs Research Topics

Disease

15	Malaria 02/2022 - 07/2014
6	Neoplasms (Cancer) 03/2016 - 10/2009
3	Infections 02/2022 - 01/2020
2	Neglected Diseases 01/2020 - 01/2017
1	Virus Diseases (Viral Diseases) 01/2022
1	Autoimmune Diseases (Autoimmune Disease) 12/2021
1	Celiac Disease (Celiac Sprue) 12/2021
1	Schistosomiasis (Bilharziasis) 01/2021
1	Rupture 12/2020
1	Chagas Disease (American Trypanosomiasis) 01/2017
1	African Trypanosomiasis (Nagana) 01/2017
1	Leishmaniasis 01/2017
1	Lymphoma (Lymphomas) 03/2016
1	Leukemia 03/2016
1	Prostatic Neoplasms (Prostate Cancer) 03/2016
1	Thrombocytopenia (Thrombopenia) 10/2014
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2014
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/2014
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 06/2014
1	B-Cell Lymphoma (Lymphoma, B Cell) 03/2011

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2011
7	Pharmaceutical PreparationsIBA 01/2021 - 12/2011
6	Antimalarials (Antimalarial Agents)IBA 12/2020 - 07/2015
4	plasmepsin (plasmepsin I)IBA 01/2020 - 07/2014
2	QuinazolinesIBA 12/2021 - 03/2011
2	Azithromycin (Zithromax)FDA LinkGeneric 01/2020 - 07/2015
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 07/2015
2	MacrolidesIBA 01/2020 - 07/2015
2	Aspartic Acid ProteasesIBA 06/2018 - 08/2015
2	AnthraquinonesIBA 03/2016 - 12/2011
1	AnthelminticsIBA 02/2022
1	CytokinesIBA 01/2022
1	PeptidomimeticsIBA 01/2022
1	AntigensIBA 12/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 12/2021
1	PiperazineIBA 03/2021
1	HydrazonesIBA 01/2021
1	ThiazolesIBA 01/2021
1	pranlukastIBA 12/2020
1	artemisinin (artemisinine)IBA 01/2020
1	artemisinIBA 01/2020
1	ElementsIBA 06/2018
1	Mitoxantrone (Novantrone)FDA LinkGeneric 03/2016
1	Biological ProductsIBA 03/2016
1	AnthracyclinesIBA 03/2016
1	A-1155463IBA 10/2014
1	WEHI-539IBA 06/2013
1	pixantrone (BBR 2778)IBA 12/2011
1	SulfonamidesIBA 03/2011

Therapy/Procedure

8	Therapeutics 03/2021 - 10/2009
1	Oral Administration 01/2020